![]() Once the spindle cell component of these tumors is identified, then the other component of giant cells also needs to be properly identified. Flow charts for the interpretation and proper classification of non-small cell carcinomas, and more specifically those with spindle cell component, are presented (see Figs. The authors 86 further proposed abandonment of the term “sarcomatoid” carcinoma, which is not helpful for targeted treatment purposes. Forty-two percent of the tumors initially labeled as sarcomatoid carcinoma were adenocarcinomas, whereas 14% were squamous carcinoma. The spindle cell component in these tumors was positive for TTF-1 in 41% of the cases, napsin A was present in 20%, keratin 5/6 in 9%, p40 in 8%, and desmocollin in 3%. 85 The study included a wide panel of antibodies, including keratin CAM5.2, keratin 7, TTF-1, napsin A, keratin 5/6, p40, desmocollin 3, Sox2, calretinin, and D2-40. More recently, we have evaluated the IHC profile of 86 cases that had been diagnosed either as spindle cell carcinomas, sarcomatoid carcinoma, or pleomorphic carcinoma with the concept of identifying specific differentiation within the spindle cell component. However, by current standards, adequate IHC analysis was not performed. 83,84 Introduced in 1994 as a description of 78 tumors with spindle cell and giant cell components, 45% of the cases showed histologic evidence of adenocarcinoma and 8% histologic evidence of squamous cell carcinoma. ![]() The term “pleomorphic carcinoma” has been used as a synonym for tumors similar to spindle cell carcinoma. In addition, even if one cannot further define some of these tumors with spindle cell morphology, the reality is that those tumors in particular may also represent a histologic variant of large cell carcinomas. Most of these cases can be categorized among the conventional subtypes of carcinoma. The term “sarcomatoid carcinoma” historically has been used to refer to spindle cell carcinomas-that is, carcinomas that have a “sarcoma-like” spindle cell morphology. Dabbs MD, in Diagnostic Immunohistochemistry, 2019 Sarcomatoid Carcinoma, Pleomorphic Carcinoma, and Giant Cell Carcinoma
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